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首页> 外文OA文献 >Virus-replicating T cells in the immune response of mice. III. Role of vesicular stomatitis virus-replicating T cells in the antibody response
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Virus-replicating T cells in the immune response of mice. III. Role of vesicular stomatitis virus-replicating T cells in the antibody response

机译：小鼠免疫应答中的病毒复制T细胞。三，水泡性口腔炎病毒复制性T细胞在抗体应答中的作用

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The functional role of the T cell (Tv) which can replicate vesicular stomatitis virus (VSV) on activation by the antigen was investigated in antibody response in vitro. By the inoculation of VSV into the culture, marked augmentation of antibody response to sheep erythrocytes (SRBC) was observed in the culture of spleen cells taken more than 3 days after the immunization with SRBC, suggesting that the VSV-susceptible suppressor cells were included in these spleen cells and the activity was eliminated by the effect of VSV. Development of two distinct types of suppressor T cells was revealed in the spleen of mice after the priming with SRBC. First, nylon wool nonadherent (NAd) suppressor T cells found in the spleen cells taken 3 days after immunization, and second, nylon wool adherent (Ad) suppressor T cells found in the spleen cells taken approximately 1 wk after immunization. The activity of nylon Ad suppressor T cells was completely abolished by VSV- preinfection, whereas that of nylon NAd suppressor T cells was unaffected. It was also shown that the helper T-cell activity was not influenced by VSV-preinfection. These results provided direct evidence that nylon Ad suppressor T cell but not nylon NAd suppressor T cell nor helper T cell can actually replicate VSV after antigenic stimulation. Thus it was strongly suggested that Tv represents the nylon Ad suppressor T cells.
机译：在体外抗体应答中，研究了可复制水泡性口腔炎病毒（VSV）的T细胞（Tv）的功能性。通过将VSV接种到培养物中，在用SRBC免疫3天后采集的脾细胞培养物中观察到对绵羊红细胞（SRBC）的抗体反应显着增强，这表明VSV易感性抑制细胞被包括在其中。这些脾细胞和活性被VSV的作用消除了。用SRBC引发后，小鼠脾脏中发现了两种不同类型的抑制性T细胞的发育。首先，免疫3天后在脾细胞中发现尼龙毛非粘附性（NAd）抑制T细胞，其次，免疫后约1周时在脾细胞中发现尼龙毛粘附性（Ad）抑制T细胞。 VSV-预感染完全消除了尼龙Ad抑制T细胞的活性，而尼龙NAd抑制T细胞的活性不受影响。还显示出辅助性T细胞活性不受VSV预感染的影响。这些结果提供了直接的证据，即抗原刺激后，尼龙Ad抑制T细胞而不是尼龙NAd抑制T细胞或辅助T细胞实际上可以复制VSV。因此，强烈建议Tv代表尼龙Ad抑制剂T细胞。

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